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Study suggests prescribing of baclofen for alcohol dependence 'should be reconsidered'

Recent trials have suggested high doses of the GABA-b agonist baclofen can be effective in the treatment of alcohol dependent patients. These studies, coupled with individual patient testimonies, have given baclofen a high public profile, prompting the French authorities in 2014 to give permission to physicians to prescribe high doses baclofen for alcohol-dependent patients, pending results from ongoing randomized clinical trials. Even before that permission, more than 200,000 persons had used baclofen "off label" in France alone. Baclofen is licenced for use as a skeletal muscle relaxant for spasms (spasticity). Now researchers from the Netherlands have carried out the largest randomised controlled trial (RCT) on baclofen for alcohol dependence so far. Their report, published in the peer-reviewed journal European Neuropsychopharmacology (December 2016), indicates that the effects of the drug may add little to the effect provided by psychosocial treatment. 151 alcoholi...

Use your words: Written prisoner interactions predict whether they’ll clean up their acts

The relationships between prisoners enrolled in "therapeutic communitie s," groups that focus on rehabilitation from drug and alcohol addiction, are key to those programs' effectiveness, said researcher Keith Warren, an associate professor of social work at The Ohio State University. And the theory behind these efforts rests on the idea that peer interaction will support learning that displaces ingrained (and unhealthy) ways of thinking that stand in the way of people leaving addiction behind. In this study, the first to test that theory, Warren and co-author Nathan Doogan, a postdoctoral researcher in Ohio State's College of Public Health, analyzed tens of thousands of written communications collected at four minimum-security facilities in Ohio with programs designed as an alternative to traditional prison time. The more a participant's language choices changed during rehab, the less likely he was to return to prison, they found. The study was published ...

Baby boomers on dope: Recreational marijuana use is on the rise among adults over 50

There is a common misperception that widespread marijuana use is limited to younger generations. However, the Baby Boomer generation has reported higher rates of substance use than any preceding generation. "Given the unprecedented aging of the U.S. population, we are facing a never before seen cohort of older adults who use recreational drugs," says Benjamin Han, MD, MPH, a geriatrician and health services researcher at the Center for Drug Use and HIV Research (CDUHR) and in the Division of Geriatric Medicine and Palliative Care at NYU Langone Medical Center (NYULMC). "With the increased availability of legalized marijuana, there is an urgent need to understand the prevalence of its use and also its effects among older generations," continued Dr. Han. "The paucity of knowledge in this area constrains the care for a changing demographic of older adults with higher rates of substance use." To address this, Dr. Han and his team led a study, "...

Long-term, low-intensity smoking associated with increased risks of death

Tobacco smoking is a public health issue around the world, estimated to cause 5 million deaths annually. However, there are few data on the effects of long-term, low-intensity smoking and a perception among some people that such a level can be safe. Maki Inoue-Choi, Ph.D., M.S., of the National Cancer Institute, Rockville, Md., and coauthors examined associations between long-term smoking of fewer than one or 1 to 10 cigarettes per day with the risk of death among current and former smokers. The study included 290,215 older adults (ranging in age from 59 to 82) who completed the 2004-2005 questionnaire in the National Institutes of Health -- AARP Diet and Health Study. The questionnaire assessed lifetime smoking intensity during previous age periods from less than 15 years old to 70 or more. Among the group, there were 22,337 current smokers (7.7 percent), 156,405 former smokers (53.9 percent) and 111,473 never smokers (38.4 percent). Compared with individuals who never smok...

Beware: Children can passively 'smoke' marijuana, too

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Marijuana joint. Credit score: © johny87 / Fotolia Stress-free with a joint round kids isn't very sensible. Not solely do children inhale dangerous secondary smoke within the course of, however the psychoactive chemical compounds within the drug are taken up by their our bodies as nicely. This warning comes from Karen Wilson of the Icahn Faculty of Medication at Mount Sinai and the American Academy of Pediatrics Julius B. Richmond Middle of Excellence within the US. She led the primary examine displaying that it's potential to select up traces of THC, the first psychoactive chemical in marijuana, within the urine of kids uncovered to secondary marijuana smoke. The findings are printed in Springer Nature's journal  Pediatric Analysis . The 2 main energetic parts in marijuana are the psychoactive chemical delta9-tetrahydrocannabinol (THC), and the nonpsychoactive cannabidiol (CBD). Earlier analytical strategies had been largely d...

Compulsory drug detention centers ‘have no role’ in treatment of opioid addiction, according to study

Approximately 600,000 people are detained in compulsory drug detention centres without due process in East and South East Asia each year, despite reported human rights abuses and lack of evidence that they effectively treat addiction. This study is the first to examine the risk of relapse from compulsory centres and concludes that they have no role in the treatment of opioid addiction. It strongly supports international calls for all countries to eliminate compulsory drug detention centres, and scale up evidence-based treatments such as methadone in voluntary community treatment settings. In 2012, the United Nations called for the closure of compulsory drug detention centres, which do not have legal oversight and detain people for prolonged periods on the basis of suspected or actual drug use, without court process. They are similar to prisons in that they result in concentrated settings of people who use drugs and, due to their ineffectiveness, result in alarming rates of drug...

Heavy alcohol use changes adolescents' brains

The study performed magnetic resonance imaging of the brain structure on young and healthy, but heavy-drinking adults who had been heavy drinkers throughout their adolescence, as well as on age-matched light-drinking control participants. They participated in three cross-sectional studies conducted over the course of ten years, in 2005, 2010 and 2015. The participants were 13 to 18 years old at the onset of the study. All participants were academically successful, and the prevalence of mental healt h problems did not differ between the two groups. Although the heavy-drinking participants had used alcohol regularly for ten years, approximately 6-9 units roughly once a week, none of them had a diagnosed alcohol use disorder. Magnetic resonance imaging of the brain revealed statistically significant differences between the groups. Among the heavy-drinking participants, grey matter volume was decreased in the anterior cingulate cortex bilaterally as well as in the right insula. ...